Hydroquinone Cream



Hydroquinone Cream is a skin-lightening cream that reduces the amount of melanin in the skin. It is used to treat melasma, a condition causing patches and spots on the facial region. Other than melasma, freckles, and lentigines, acne scars respond well to the use of Hydroquinone. It is available in OTC and prescription versions in 2% and 4% concentrations.

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Hydroquinone cream Singapore

Hydroquinone Cream in Singapore is available in over-the-counter and Prescription forms. Over the Counter versions of the medications are usually the lower strengths that can be obtained without a prescription. Higher strengths of the medication are prescription based, with their use strictly regulated by the FDA.
You can obtain prescription Hydroquinone cream in Singapore from pharmacies or a few private clinics dispensing the medication. You can even order it through registered online portals that will evaluate your condition and provide you with a prescription, after which the pharmacy will deliver it safely. Alternatively, you can provide a pre-existing prescription in the portal to avail of the cream.


Dose                                   Twice a day by rubbing gently on affected areas

Strength                           Hydroquinone 2% and 4% cream and hydroquinone 2% gel.

Active ingredient        Hydroquinone

Side effects                    Redness, itching, flakiness,

The dose provided is from the consumer medicines information leaflet. Always use your prescription medication as prescribed by the doctor. For a full list of side effects, read the consumer medicines information.

Medication Features

  1. Depigmentation or skin-lightening agent
  2. Available in OTC and prescription form
  3. 20mg, 25mg and 30mg tubes
  4. Available in brand and generic versions
  5. 2% and 4%
  6. Cream form and gel form

Side Effects

Mild side effects –               Mild burning or stinging of treated skin, mild tingling sensation of skin

Moderate side effects –     Blue and black discoloration of the skin, photosensitivity reactions,

Severe side effects –           Severe burning and blistering of the skin, rashes throughout the skin surface

Wait for the cream to dry before applying makeup, moisturizer, sunscreen, or other topical products. Be careful while applying the cream near the eyes, nostrils, and mouth. If your melasma-affected skin is close to these areas, consider using a cotton swab to apply the cream for user safety.

To avoid side effects associated with the use of the cream, use sunscreen with the medication and wear protective clothing. In case the side effects are not reversed even after regular use or are further intensified, discontinue the use of the cream and get urgent medical attention

Note:- Hydrocortisone is an anti-inflammatory topical steroid cream. Hydroquinone is a skin-bleaching agent that works by inhibiting the production of melanin.


The price of Hydroquinone cream depends on the version you are ordering and the strength of the medication. OTC versions of Hydroquinone cream are lower priced, while Prescription versions have an increased cost because of the improved medication concentration.

Frequently Asked Questions

What happens when you stop using Hydroquinone Cream?

Hydroquinone is an inflammatory agent that can become allergenic after five months. Hydroquinone-induced inflammation can cause rebound hyperpigmentation and reduced tolerance to the medication. Once you stop using Hydroquinone cream, you may experience irritation on the affected parts of the skin and inflammation resulting from building resistance to the treatment after a certain time. To avoid such complications, opt for a pulsed approach to Hydroquinone, i.e., limit the use of Hydroquinone to no longer than five months. Then, give your skin a break; allow it to rest and stabilize for 2-3 months as you use non-hydroquinone pigment control products to prevent rebound pigmentation. After the break, your physician can decide if another five-month course of Hydroquinone is appropriate for your condition.

Where to buy Hydroquinone 4 cream?

Hydroquinone 4 cream is a prescription medication and not readily available over the counter. You need a physician’s prescription to diagnose your condition to avail of the medication from pharmacies or private clinics. You can order Hydroquinone 4 cream online, which will deliver the medication to your doorstep in a safe manner. For online ordering, you can either provide the site with an existing prescription or obtain one after an online consultation. It is important to check the correct dosage before and after ordering Hydroquinone cream for safety reasons. Opt for an authentic site that supplies you with genuine medication.

How often should you use Hydroquinone 4%?

Hydroquinone 4% cream can be used safely twice daily for up to 6 months to treat post-inflammatory hyperpigmentation. Short-term use is the best way of obtaining satisfactory results from the medication in a safe manner. You can apply twice daily for at least six weeks, limiting its usage to six months for best results.

The efficacy of this Hydroquinone treatment can be further enhanced by using a retinoid cream nightly and a mid-potent steroid. Excessive hydroquinone concentrations may induce toxic or shocking effects on melanocytes, forcing them to regroup and increase their melanin production resulting in rebound hyperpigmentation and even leading to skin inflammation, and must be avoided at all costs.

What percentage of Hydroquinone is effective for hyperpigmentation?

Both 2% and 4% Hydroquinone are effective for hyperpigmentation, but quicker and long-lasting results are obtained from the 4% strength of the medication. But hydroquinone side effects and irritation symptoms are greater in higher doses. A study testing a hydroquinone monotherapy indicated an 85% satisfaction rate after 12 weeks, with 90% of participants reporting that they no longer made significant efforts to hide skin discoloration. It takes three months for the medication to start working effectively in hyperpigmentation reduction. Still, in extensive pigmentation conditions or using lower-strength Hydroquinone, it may take longer.

What happens if you use Hydroquinone for too long?

Long-term use of Hydroquinone can give rise to the phenomenon of ochronosis. An uncommon disorder characterized by a clinical appearance of blue-black or gray-blue pigmentation with the histological finding of yellow-brown deposits in the dermis. Most often, the skin, sometimes the ears’ cartilage, and the eyes’ sclera are affected by ochronosis. Hydroquinone should be applied twice daily for 2–6 months and discontinued if positive results are not seen even after two months. Therapy beyond six months is not expected to yield additional improvement. In other conditions, Hydroquinone can be used twice daily for up to five months consecutively, after which melanocytes should be allowed to stabilize during a two to three-month break from Hydroquinone.

Additional information


2tube, 4tube, 6tube


2%, 4%


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