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Erectile Dysfunction impacts 15 million people each year and significantly affects their quality of life. Research has consistently shown that erectile dysfunction can cause serious distress in men and that this distress can impact self-esteem and the quality of relationships.
In a study conducted between 2 groups – Group 1, containing 40 patients between the age of 18-70 diagnosed with ED, and Group 2, having 40 patients who applied to the Urologic Clinic for various reasons without ED. Significant differences were found between the two groups in IIEF-5 ( International Index of Erectile Dysfunction ), RESQ ( Rosenberg Self-Esteem Questionnaire ), and BDI-2 scores ( Beck-Depression Questionnaire ). In Group 1, the IIEF-5 score was low, and RESQ and BDI-2 scores were significantly higher, interpreted as poor sexual function resulting in reduced self-esteem and moderate-severe depressive tendencies.
As a sum total of analysis and trials, researchers have concluded that people significantly reflect their sexual satisfaction in their social lives and thus remain unsatisfied even in mild ED conditions. The situation results in substantially lower self-esteem that needs immediate treatment measures to improve penile function with social function.
Usually, PDE-5 inhibitors in the form of Sildenafil, Vardenafil, and Tadalafil are considered the chief treatment options, out of which Sildenafil, because of its bioavailability benefits and improved effect on sexual arousal. While the brand version of Sildenafil is more sought after, it is expensive and sometimes out of the means of the general population. In comparison, generic Sildenafil in the form of Kamagra oral jelly is cost-effective and thus more popular.
Kamagra oral jelly is one such generic Sildenafil derivative that shares the same mechanism and pharmacological properties of Viagra but is easily digestible and works in less time because of its sublingual properties.
How does Kamagra oral jelly work on the psychological aspects of Erectile Dysfunction
Erectile Dysfunction is often characterized by psychological symptoms like irritability, anxiety, performance anxiety, and increasing levels of frustration that impede depressive tendencies when not provided with adequate and timely treatment.
Other than the prominent effects of Sildenafil, the active ingredient of Kamagra oral jelly, on the Nitric-Oxide mediated vasodilation in the Corpus Cavernosum, recent research has shown that local Sildenafil administration enhances dopamine levels in the nucleus accumbens, the neural interface between motivation and action, playing a key role on feeding, sexual, reward, stress-related behaviors of the person.
Image Credit – https://www.mdpi.com/2218-273X/11/12/1866
Dopamine is a neurotransmitter concerned with movement, memory, and pleasurable reward and motivation; enhanced dopamine levels caused by the Sildenafil action enhance confidence and performance and help overcome the stress caused by impaired erectile function. Animal studies have even shown Sildenafil administration to impact the serotonergic activity in the medial preoptic area of the brain, a critical integrative site for male copulatory behavior in most vertebrate species responsible for releasing extracellular dopamine before and after copulation.
Animal Studies on Sildenafil Kamagra oral jelly’s Impact on sexual confidence
In in vitro trials where acute, ( 2 days ) or chronic ( 21 days ) Sildenafil regimen of 1mg/kg was administered intraperitoneally ( within the peritoneal cavity containing the abdominal organs), the male subjects, half of whom had previous experience of non-contact sexual encounter and the other half that was exposed for the first time were exposed to non-contact erection sessions to female subjects of the similar species.
Tissue levels of Extracellular- Dopamine and its metabolites, 3,4-Dihydroxyphenylacetic acid (DOPAC, related to the reward and pleasure centers of the brain) and homovanillic acid (HVA), as well as serotonin (5-HT) and its metabolite 5-HIAA, were measured in the mPOA and NAcc with high-performance liquid chromatography with an electrochemical detector. Dopamine ([DOPAC+HVA]/DA) and serotonin (5-HIAA/5-HT) turnovers were also calculated as indices of neurotransmission. In untrained rats, acute and chronic Sildenafil treatment increased Extracellular Dopamine and Serotonin in the nucleus accumbens and medial preoptic brain areas.
In trained rats, acute Sildenafil/Kamagra Oral Jelly use increased extracellular Dopamine and Serotonin levels in the brain’s nucleus accumbens and medial preoptic areas. Chronic Sildenafil treatment increased the Serotonin turnover rate only in the medial preoptic area and the extracellular turnover rate only in the nucleus accumbens. Based on the study results, it is safe to conclude that Sildenafil enhances dopaminergic activity in the nucleus accumbens and impacts the serotonin levels in the medial preoptic region.
Based on the study results, it is safe to conclude that Sildenafil/Kamagra Oral Jelly enhances dopaminergic activity in the nucleus accumbens and impacts the serotonin levels in the medial preoptic region. Dopamine has facilitative effects on copulatory proficiency with control over genital reflexes and sexual motivation. Serotonin is a combination of inhibitory and stimulatory, with stimulatory effects increasing erections and inhibiting ejaculation, with its inhibitory effects delay the ejaculation process and the onset of copulation.
The overall effect is a healthy genital reflex with a timely copulatory pattern that can ease the sexual process and restore the sexual confidence previously hampered by defective erection. Therefore, the present findings support the effect of Sildenafil on central neural pathways involved in controlling sexual arousal. Kamagra Oral Jelly is a prominent Sildenafil derivative that can positively increase the dopamine and serotonin concentrations in the CNS and influence sexual confidence by positively impacting sexual motivation, controlled genital reflexes, and adequate copulatory pattern.
Human studies about Kamagra oral jelly’s Role in restoring sexual confidence
Other than animal studies, human-based clinical trials have observed higher satisfaction levels as assessed with the Erectile Dysfunction Inventory of Treatment Satisfaction – a validated 11-item questionnaire used to evaluate treatment satisfaction and the likelihood of treatment continuation in patients with ED. ED patients and their partners reported higher EDITS scores with Sildenafil than those receiving the comparison placebo treatment.
Other than EDITS 11-item questionnaire, other clinical-based trials assessed by a 5-item scale and correlated with ED severity and etiology have observed high levels of treatment satisfaction with Sildenafil/ Kamagra Oral Jelly medication. Sildenafil also improved all aspects of health-related quality of life assessed by SF-36, Q13, or Q14 of the IIEF in the general ED population or subgroups such as spinal cord injuries.
SF-36 – used to indicate the health status of particular populations, to help with service planning, and to measure the impact of clinical and social interventions. The lower the score, the more disability.
Q13 OF IIEF – How satisfied have you been with your overall sex life?
Q14 OF IIEF – How satisfied have you been with your sexual relationship with your partner?
Significant improvements in self-esteem, confidence, sexual relationship satisfaction, and overall relationship satisfaction after treatment of ED with Sildenafil/Kamagra Oral Jelly were reported using the self-esteem and relationship questionnaire (SEAR) in a cross-cultural double-masked, placebo-controlled, flexible-dose study. Treatment satisfaction that was obtained through Sildenafil/Kamagra Oral Jelly use was also maintained over time.
Image Credit – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699643/
While Kamagra oral jelly has not been actively used in clinical trials and animal studies, Sildenafil, through evaluation of several clinical studies and meta-analysis reports, has shown that the medication can restore sexual confidence by treating the physiological and psychological aspects of the problem with satisfactory results. Sildenafil Kamagra Oral jelly even comes useful in ED conditions brought about by neurologic, diabetes, vasculogenic ( obesity, high blood pressure, coronary artery disease ), and psychogenic causes ( because of stress, childhood sexual abuse, performance anxiety, conflicts in relationships), and ensures that you have a longer, uninterrupted sexual activity phase with enhanced mood and sans copulation inhibitions. Ensure you use it under the physician’s guidance for patient safety and optimum results.